Crowds waving Israeli flags set off from the Damascus Gate – the main entrance to the Muslim quarter of Jerusalem’s Old City – dancing and chanting “The people of Israel live” and “Death to the Arabs.”
Israeli police in riot gear blocked nearby streets, forcibly removing Palestinian demonstrators from the route.
According to the Palestinian Red Crescent Society, 79 Palestinians were wounded in Jerusalem by rubber bullets, stun grenades and pepper spray, and one protester was shot dead with live ammunition.
According to the agency, 28 people were evacuated to hospital after clashes with Israeli security forces and Israeli demonstrators.
At least 163 Palestinians were also injured in the West Bank. According to the Red Crescent, at least 11 of those wounds were inflicted by live bullets.
More than 50 people were arrested and detained for participating in the riot and attacking police officers, the Israeli police said in a statement on Sunday.
The police also said that five police officers were slightly injured in various incidents and needed medical attention. More than 2,000 police officers and volunteers were deployed throughout Jerusalem.
The Flag March is an annual parade in which mostly nationalist Jewish groups celebrate Israel’s gaining control of the Western Wall during the 1967 Six-Day War and the capture of East Jerusalem, bringing the entire city under Israeli control.
The march had also been a flashpoint for Palestinian residents of the Old City in previous years.
Reporting by CNN correspondents Atika Schubert, Abir Salman and Lauren Izso in Jerusalem and Celine Alhaldi in Amman.