Around noon local time on Sunday, patrol guards noticed that the middle-aged victim climbed over a high mesh fence and entered the enclosure with a lion, a lioness and two cubs.
His motivation has not yet been determined.
“The attacker was attacked and injured by one of the lions,” the State Forestry Commission said Sunday, adding that the man died from injuries sustained during the attack.
Authorities are investigating the incident.
The statement said that none of the animals escaped during the incident and the enclosure remains safe.
The lions are the main attraction at the Accra Zoo, where a reinforced mesh fence allows visitors to observe the predators up close.